Protein Details: Voltage-gated sodium channel subunit beta-3

Protein ID

ICDB_Pro_1540

Protein Name

Voltage-gated sodium channel subunit beta-3

Gene Name

Scn3b

Organism

Rattus norvegicus (Rat)

Length

215 amino acids

AlphaFoldDB

AF-Q9JK00-F1-model_v4.pdb

Function

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

Sequence

MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed broadly in neurons in the central and peripheral nervous systems; but not in glia and most non-neuronal cells. Weak detection in lung and adrenal gland. . . .

DOI ID

10.1073/pnas.030362197; 10.1006/mcne.2001.1039; 10.1101/gr.2596504; 10.1083/jcb.200102086; 10.1016/j.bbrc.2004.05.026

RefSeq

NP_620797.1; XP_006243164.1; XP_006243165.1